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      83207-58-3

      • Product Name:Astragaloside A
      • Molecular Formula:C41H68O14
      • Molecular Weight:784.983
      • Appearance:white powder
      Inquiry

      Product Details

      pd_meltingpoint:284-286oC

      Appearance:white powder

      Purity:99%

      Trustworthy Factory Supply Astragaloside A, Factory Sells 83207-58-3 with Lowest Price

      • Molecular Formula:C41H68O14
      • Molecular Weight:784.983
      • Appearance/Colour:white powder 
      • Vapor Pressure:0mmHg at 25°C 
      • Melting Point:284-286oC 
      • Refractive Index:1.62 
      • Boiling Point:895.666 °C at 760 mmHg 
      • PKA:12.91±0.70(Predicted) 
      • Flash Point:495.481 °C 
      • PSA:228.22000 
      • Density:1.395 g/cm3 
      • LogP:0.72410 

      Astragaloside A(Cas 83207-58-3) Usage

      Description

      Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.

      Uses

      Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

      Health effects

      As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

      Pharmaceutical Applications

      Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

      InChI:InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27?,28-,29+,30?,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

      83207-58-3 Relevant articles

      TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. XV. CYCLOSIVERSIOSIDES B AND D FROM Astragalus basineri

      Umarova, R. U.,Svechnikova, A. N.,Abdullaev, N. D.,Gorovich, M. B.,Abubakirov, N. K.

      , p. 174 - 177 (1984)

      Two new glycosides have been isolated fr...

      Functional Characterization and Protein Engineering of a Triterpene 3-/6-/2′-O-Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity

      Bao, Yang-Oujie,Gao, Bai-Han,Li, Fu-Dong,Qiao, Xue,Shi, Xiao-Meng,Su, Hui-Fei,Wang, Hai-Dong,Ye, Min,Yi, Yang,Zhang, Meng

      supporting information, (2022/01/06)

      Engineering the function of triterpene g...

      Synthetic Access Toward Cycloastragenol Glycosides

      Liu, Ting,Liao, Jin-Xi,Hu, Yang,Tu, Yuan-Hong,Sun, Jian-Song

      , p. 4170 - 4178 (2017/04/27)

      The first efficient synthetic approach t...

      Triterpene glycosides from Tragacantha stipulosa and their genins. Structure of cyclostipuloside E

      Kaipnazarov,Uteniyazov,Saatov

      , p. 40 - 44 (2007/10/03)

      The known compound trojanoside A(1) and ...

      83207-58-3 Process route

      3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol

      3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol

      astragaloside IV
      83207-58-3,84687-43-4

      astragaloside IV

      Conditions
      Conditions Yield
      With sodium methylate; In methanol; at 20 ℃; for 15h;
      76%
      astragaloside VI
      84687-45-6

      astragaloside VI

      astragaloside IV
      83207-58-3,84687-43-4

      astragaloside IV

      Conditions
      Conditions Yield
      hesperidinase; In water; acetone; at 35 ℃; for 36h;
      35 mg

      83207-58-3 Upstream products

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        88192-83-0

        cyclosiversioside H

      • 86764-11-6
        86764-11-6

        isoastragalosides II

      • 84676-88-0
        84676-88-0

        isoastragaloside I

      • 84687-46-7
        84687-46-7

        (3β,6α,16β,20R,24S)-20,24-epoxy-16-hydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-6,25-diyl bis[β-D-glucopyranoside]

      83207-58-3 Downstream products

      • 84605-18-5
        84605-18-5

        cycloastragenol

      • 86764-12-7
        86764-12-7

        cyclosieversigenin 6-O-β-D-glucopyranoside

      • 86541-79-9
        86541-79-9

        astragenol

      • 86541-83-5
        86541-83-5

        cyclosieversigenin 3-O-β-D-xylopyranoside

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